Mapt CLIA Kit for Rat(Rattus norvegicus) | EIAab.comMapt CLIA Kit for Rat(Rattus norvegicus)

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Mapt (Gene name),

Microtubule-associated protein tau (Protein name ), TAU_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Mapt(Mtapt;Tau);

Protein name:

Microtubule-associated protein tau;

Alternative:

Paired helical filament-tau(PHF-tau);Neurofibrillary tangle protein;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts with SQSTM1 when polyubiquitinated. Interacts with PSMC2 through SQSTM1 (By similarity). Interacts with FKBP4.

Function:

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Subcellular Location:

Cytoplasm cytosol Cell membrane Peripheral membrane protein Cytoplasmic side Cytoplasm cytoskeleton Cell projection axon Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components.

Protein Attributes:

Sequence length:

752

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

752:

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00418

UniGene:

Rn.2455

String:

P19332

Uniprot:

P19332

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ELISA Kit for Rat Microtubule-associated protein tau

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E1983h

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96T

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ELISA Kit for Rat Microtubule-associated protein tau

Cat.:

E1983r

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96T

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ELISA Kit for Rat Microtubule-associated protein tau

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E1983m

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ELISA Kit for Rat Microtubule-associated protein tau

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E1983b

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96T

CLIA Kit for Rat Microtubule-associated protein tau

Cat.:

U1983h

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96T

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CLIA Kit for Rat Microtubule-associated protein tau

Cat.:

U1983m

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96T

CLIA Kit for Rat Microtubule-associated protein tau

Cat.:

U1983b

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96T

CLIA Kit for Rat Microtubule-associated protein tau

Cat.:

U1983r

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96T

Polyclonal Antibody for Rat Microtubule-associated protein tau

Cat.:

P1983Rb-r

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40ug/0.2ml

Polyclonal Antibody for Rat Microtubule-associated protein tau

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P1983Rb-m

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40ug/0.2ml

Polyclonal Antibody for Rat Microtubule-associated protein tau

Cat.:

P1983Rb-h

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40ug/0.2ml

Monoclonal Antibody for Rat Microtubule-associated protein tau

Protein for Rat Microtubule-associated protein tau

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Cloning of a big tau microtubule-associated protein characteristic of the peripheral nervous system."
Goedert M. , Spillantini M.G. , Crowther R.A.
Proc. Natl. Acad. Sci. U.S.A.89:1983-1987(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM TAU-B)
tissue: Pheochromocytoma.
2.

"Expression of high molecular weight tau in the central and peripheral nervous systems."
Georgieff I.S. , Liem R.K.H. , Couchie D. , Mavilia C. , Nunez J. , Shelanski M.L.
J. Cell Sci.105:729-737(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM TAU-B)
tissue: Spinal ganglion.
3.

"Complete sequence of 3'-untranslated region of tau from rat central nervous system. Implications for mRNA heterogeneity."
Sadot E. , Marx R. , Barg J. , Behar L. , Ginzburg I.
J. Mol. Biol.241:325-331(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM TAU-F)
strain: Wistar.
tissue: Brain.
4.

"Developmentally regulated expression of specific tau sequences."
Kosik K.S. , Orecchio L.D. , Bakalis S. , Neve R.L.
Neuron2:1389-1397(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS TAU-E AND TAU-G)
tissue: Brain.
5.

"Expression of multiple tau isoforms and microtubule bundle formation in fibroblasts transfected with a single tau cDNA."
Kanai Y. , Takemura R. , Oshima T. , Mori H. , Ihara Y. , Yanagisawa M. , Masaki T. , Hirokawa N.
J. Cell Biol.109:1173-1184(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS TAU-E AND TAU-C)
6.

"Diversity of high-molecular-weight tau proteins in different regions of the nervous system."
Mavilia C. , Couchie D. , Nunez J.
J. Neurochem.63:2300-2306(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE OF 360-461 (ISOFORM TAU-A);NUCLEOTIDE SEQUENCE OF 106-113 AND 368-461 (ISOFORM TAU-D)
tissue: Spinal cord.
7.

"In vivo phosphorylation sites in fetal and adult rat tau."
Watanabe A. , Hasegawa M. , Suzuki M. , Takio K. , Morishima-Kawashima M. , Titani K. , Arai T. , Kosik K.S. , Ihara Y.
J. Biol. Chem.268:25712-25717(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 492-501; 506-515; 523-532; 537-551 AND 698-726;PHOSPHORYLATION AT THR-492; SER-509; SER-510; SER-513; THR-528; THR-542; SER-546; SER-707; SER-711 AND SER-715
8.

"Molecular diversity at the carboxyl terminus of human and rat tau."
Sawa A. , Oyama F. , Matsushita M. , Ihara Y.
Brain Res. Mol. Brain Res.27:111-117(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 697-752 (ISOFORMS TAU-A; TAU-B; TAU-C; TAU-D; TAU-E; TAU-F AND TAU-G);NUCLEOTIDE SEQUENCE [MRNA] OF 752-775 (ISOFORM TAU-H)
strain: Sprague-Dawley.
tissue: Brain.
9.

"A role for FKBP52 in Tau protein function."
Chambraud B. , Sardin E. , Giustiniani J. , Dounane O. , Schumacher M. , Goedert M. , Baulieu E.E.
Proc. Natl. Acad. Sci. U.S.A.107:2658-2663(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FKBP4

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